Innovative initiatives that support the city's plan for the new economy include:

Small Business Technology and Development Center
The Small Business and Technology Development Center, a business development service of the University of North Carolina System at Winston-Salem State University, provides management counseling, educational services, and technical assistance to foster technological development, commercialization, and the creation and expansion of small- to medium-sized enterprises.

Piedmont Triad Entrepreneurs Network
PTEN seeks to create an environment conducive to the growth and development of entrepreneurial business in the Piedmont Triad. It promotes access to capital and creates programs that enlighten people about business, management, marketing, and finance.

Greater Winston-Salem Chamber of Commerce
The Greater Winston-Salem Chamber of Commerce is a leading business organization in Winston-Salem and Forsyth County, representing more than 2,000 area businesses. The chamber offers services to strengthen existing businesses, to encourage small business creation, and to develop a talented workforce. With a record of accomplishments spanning 116 years, the Greater Winston-Salem Chamber of Commerce is a proven catalyst for strengthening the community as it helps build businesses.

Winston-Salem Business Inc. (WSBI)
Winston-Salem Business Inc. is the only local agency that conducts external economic development marketing. WSBI promotes Winston-Salem and Forsyth County as an excellent business location and provides unparalleled customer service to clients and consultants interested in locating businesses in our community. From manufacturing to information technologies, WSBI focuses on bringing new companies and their latest technologies to the area. The annual marketing efforts include targeting industries and companies in specific sectors (Medical/Biotech, Financial Services, Distribution/Logistics and Advanced Manufacturing) through various media including print advertising, direct mail, website, email newsletter, direct visits, events, and trade shows. The current campaign focuses on the overall quality of life aspect of businesses and their employees in the community entitled, "Winston-Salem, Where Business Lives."